Department of Operation and Organization : mainly responsible for administrative affairs, building and facilities, safety and security, operational management and overall coordination.

Department of Exhibition and Display : mainly responsible for the content research, design, planning of exhibitions as well as exhibition arrangements and construction.

Department of Collection and Conservation : mainly responsible for the collection and storage of exhibits as well as the operation of the official website and the development of the digital museum.

Department of Social Education: responsible for guiding tours, planning and organizing community educational activities and outreach programs, as well as volunteer management.

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Qian Xuesen Research Center, Shanghai Jiao Tong University: mainly engaged in the researches on Qian's life and career, his scientific thinking and also other scientists who contributed to the "two-bombs-one-satellite" (China’s project.